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in breast milk; by intravenous drug use or blood transfusions; or by sexual contact The age of onset is in mid adult life, and it is more common in females than in males, in a ratio of 3:1 The clinical and pathologic features of the disease are described in Chap 44, on spinal cord disorders, and in several recommended reviews (Rodgers-Johnson et al); the differentiation from the progressive spinal form of multiple sclerosis, with which it is most likely to be confused, is discussed on page 785 There are also clinical and pathologic differences from the myelopathy caused directly by HIV infection No form of treatment has proved effective in reversing this disorder, although there are anecdotal reports that the intravenous administration of immune globulin may halt its progress The retrovirus HTLV-II is less common than HTLV-I but the two are virologically very similar There is a high rate of infection with HTLV-II among drug users who are coinfected with HIV A few cases of myelopathy have been reported in HTLV-II infected patients, similar in all respects to HTLV-I associated myelopathy (Lehky et al) Viral Infections of the Developing Nervous System Viral infections of the fetus, notably rubella and CMV, and HSV infection of the newborn are important causes of CNS abnormalities They are considered in Chap 38, under Developmental Diseases of Infancy and Childhood

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For the Macintosh and Windows systems, you will find the popular Dreamweaver web development program from Adobe that has support for both ASPNET and C# Because ASPNET 35 is so new, you ll need to get whatever version of Dreamweaver is released after the official release of ASPNET 35 to ensure full compatibility If you have an older version of Dreamweaver, though, you can still get some valuable help from Dreamweaver For example, Figure 2-13 shows how Dreamweaver has a context menu that displays selections of ASPNET web forms and other available options You should also note in Figure 2-13 that rather than placing the C# code in a separate CS file using a partial class, Dreamweaver uses the embedded script method beginning on Line 4 Depending on how you like working with code-behind C#, this alternative embedded style may or may not be your preference Using Dreamweaver, you will have to use an online ASPNET hosting service because you cannot test your applications as you develop them as with Visual Studio 2008

943) And, of course, acute poliomyelitis is still a frequent illness in regions of the world where vaccines are not available For these reasons and also because it stands as a prototype of a neurotropic viral infection, the main features of the disease should be known to neurologists Etiology and Epidemiology The disease is caused by a small RNA virus that is a member of the enterovirus group of the picornavirus family Three antigenically distinct types have been de ned, and infection with one does not protect against the others The disease has a worldwide distribution; the peak incidence of infection in the northern hemisphere was in the months of July through September Poliomyelitis is a highly communicable disease The main reservoir of infection is the human intestinal tract (humans are the only known natural hosts), and the main route of infection is fecaloral, ie, hand to mouth, as with other enteric pathogens The virus multiplies in the pharynx and intestinal tract During the incubation period, which is from 1 to 3 weeks, the virus can be recovered from both of these sites In only a small fraction of infected patients is the nervous system invaded Between 95 and 99 percent of infected patients are asymptomatic or experience only a nonspeci c illness It is the latter type of patient the carrier with inapparent infection who is most important in the spread of the virus from one person to another Clinical Manifestations The large majority of infections are inapparent, or there may be only mild systemic symptoms with pharyngitis or gastroenteritis (so-called minor illness or abortive poliomyelitis) The mild symptoms of poliomyelitis correspond to the period of viremia and dissemination of the virus; they give rise in most cases to an effective immune response a feature that accounts for the failure to cause meningitis or poliomyelitis In the relatively small proportion of patients in whom the nervous system is invaded, the illness still has a wide range of severity, from a mild attack of aseptic meningitis (nonparalytic or preparalytic poliomyelitis) to the most severe forms of paralytic poliomyelitis Nonparalytic or Preparalytic Poliomyelitis The prodromal symptoms consist of listlessness, generalized, nonthrobbing headache, fever of 38 to 40 C (1004 to 104 F), stiffness and aching in the muscles, sore throat in the absence of upper respiratory infection, anorexia, nausea, and vomiting The symptoms may subside to a varying extent, to be followed after 3 to 4 days by recrudescence of headache and fever and by symptoms of nervous system involvement; more often the second phase of the illness blends with the rst Tenderness and pain in the muscles, tightness of the hamstrings (spasm), and pain in the neck and back become increasingly prominent Other early manifestations of nervous system involvement include irritability, restlessness, and emotional instability; these are frequently a prelude to paralysis Added to these symptoms are stiffness of the neck on forward exion and the characteristic CSF ndings of aseptic meningitis These symptoms may constitute the entire illness; alternatively, the preparalytic symptoms may be followed by paralytic ones Paralytic Poliomyelitis The weakness becomes manifest while the fever is at its height, or, just as frequently, as the temperature falls and the general clinical picture seems to be improving Muscle weakness may develop rapidly, attaining its maximum severity in 48 h or even less; or it may develop more slowly or in stuttering fashion, over a week, rarely even longer As a general rule, there is no progression of weakness after the temperature has been nor-.

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